body{font:16px/1.25 Arial;color:#272727;max-width:60em;margin:0 auto;background-color: #faf7f7;min-width:280px;}
*{box-sizing:border-box;-moz-box-sizing:border-box;-webkit-box-sizing:border-box;}
.grid{background-color: #fff;margin: auto 0;padding: 32px;border:solid 1px #d0d0d0;}
.row{overflow:auto;}
.maincontent{min-height:400px;}
img{border:0}
h1, h2, h3, h4{font-family:"Lucida Grande","Helvetica Neue",Helvetica,Arial;color:#000;}
.col_supp{line-height:18px;}
h2{font-size:18px; margin:12px auto 4px;}
a{color:#0033cc;text-decoration:none;}
a:visited{color:#4747c0;}
.copper{color: #993300;}
.light_text, .light_text *, .light_text a:visited{color:#575757;}
.medium_text, .medium_text *{color:#272727;}
.light_narrow_text, .light_narrow_text *{font-family:"Arial Narrow",helvetica,sans-serif;color:#575757;}
#logo{position:absolute;top:0px;}
.h{}
.f{padding-top:8px;font-size:12px;overflow:hidden;border-top:1px solid #d0d0d0;margin-top:2.5em;}
.f ul{float:right;display:inline;margin:0}
.f ul li{display:inline;margin-left:.3em}
.wm{padding-left:10px;}
.wm h2{padding-top:20px;margin-bottom:0.5em;}
.wm p {margin:0 0 2em;}
p{margin:8px 0;}
.sml{font-size:11px}
.sf{position:relative;}
.txt{font-size:16px;padding:4px 5px;outline:none;border:1px solid #336699;height:28px;position:relative;}
a.but{color:#fff;}
.but{padding:7px 15px;background-color:#369;min-width:50px;text-align:center;color:#fff;font-size:14px;font-weight:bold;font-family:arial,sans-serif;
text-decoration:none;border:0;border-radius:5px;*width:90px}
.srch{position:absolute;top:-50px;right:-1px}
#srch{position:absolute;top:0px;left:80px;}
#search_tg{position:absolute;right:0px;top:0px;z-index:10;}
#search_tg img{ border-radius: 0 4px 4px 0;}
#search_but{display:none;}
input {-webkit-appearance: none;border-radius: 0;}
.w{background:no-repeat scroll;background-size: 100% auto;padding-top:50%;}
#s_term{font-style:italic;}
#ac_cont{position:absolute;z-index:100;background-color:white;border:none;box-sizing: border-box;}
#ac_cont ul{margin:0;border:1px solid #336699;border-top:none;}
#ac_cont ul li{padding:2px 1px 2px 5px;}
.rel{border-top: 2px solid #97B0C8;padding:10px 0px;}
.rel strong{font-size:13px;}
.off_screen{text-indent:-9999px;height:0;margin:0;padding:0;position:absolute;}
.fil span{margin:0 0 0 5px;}
.fil a{margin:0 5px 0 0; padding-left:12px;}
.fil .fil_sel{background : url(//static.pubmed.gov/portal/portal3rc.fcgi/4079699/img/3371032) no-repeat 0px 3px;}
.aux,.avail,.p_comm{font-size:14px;}
.r li .avail a, .r li .p_comm a{display:inline;margin-right:12px;}
.a .title{font:20px;line-height:24px;margin:8px auto;}
.a{padding-top:10px;}
.a .lang{font-size:14px;}
.auths h3.label,.aff h3.label{text-indent:-9999px;height:0;margin:0;padding:0;position:absolute;}
.meta .auths p,.meta .aff p{margin:0;}
.auths .exi{margin-top:6px;}
.exi li{position: relative;padding-left: 10px;text-indent: -6px;}
.exi li sup{position:relative; left:-4px;}
.pub_type{color:#375237; font-weight:bold; font-size:13px;}
.a .pub_type{display:inline-block;margin-bottom:8px;}
#cit_summary{font-size:14px;}
.meta h3{margin-bottom:0;}
.meta ul,.meta .j{margin:2px 0;}
#see_pmcommons, .num_comments {background: url("//static.pubmed.gov/portal/portal3rc.fcgi/4079699/img/3925275") no-repeat scroll 0 1px transparent;
 margin: 0 10px 0 0;padding-left: 1.5em;text-decoration: none;font-size:14px;}
 #fft{margin: 1.5em 0 0.2em;}
 .fft{font-weight:normal;}
 .rel .jrnl{font-size:13px;}
 .rel li a{display:block;}
 .see_all{display:block;margin-bottom:10px;}
 #qlinks{font-size:14px;}
 #qlinks  a{margin-right:20px;}
#filtsort{position:relative;height:32px;font-size:14px;}
#filtsort div, #filtsort dd,#filtsort dt,#filtsort li{border-bottom:1px solid #f7f5f5;padding:2px 8px;}
#filtsort .p_footer{border-bottom:none;}
#filtsort > a{width:48%;border:1px solid #777;background-color:#F7F7F7;display:inline-block;padding:4px 32px 4px 8px;}
#filtsort a{text-decoration:none;color:#000;}
#filters_dd{left:0px;overflow:hidden;height:32px;}
#sort_dd{left:52%;overflow:hidden;height:32px;}
.pm_popper{background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4079699/img/4054496) no-repeat right top;
   width:64px;position: absolute;top:0px;left:0px;}
.popper_tg_open{}
.popper_tg_close{background-position:100% -32px;}
.popper_closed{display:none;}
.popper_opened{display:block;} 
#filtsort #filters, #filtsort #sort_options{margin:0px;padding:0;width:48%;;border:1px solid #8d8d8d;z-index: 100;
background-color:#FFF;position:absolute;}
#filters dt a,#sort_options li a{ display: inline-block;padding-left: 12px;width: 100%;}
#sort_options .selected,#filters .selected{background : url(//static.pubmed.gov/portal/portal3rc.fcgi/4079699/img/3371032) no-repeat;background-position : 0 4px;}
#filters dl{margin: 0px;}
#filters dd{background-color: #f7f7f2;margin-left: 0;border-top: 1px solid #ddd;}
#filters dt{padding-left: 12px;}
.filtsort_msg{margin-top:5px;}
.filt_applied{padding-right:10px;margin-right:8px;text-decoration:none;color:black;background : url(//static.pubmed.gov/portal/portal3rc.fcgi/4079699/img/4040682) no-repeat top right;
background-color:rgba(207, 207, 248, 1); border-radius:2px; padding-left:3px;white-space:nowrap;display:inline-block;margin-bottom:10px;}
#filtsort .p_header, #filtsort .p_footer {background-color:#eee;padding:8px 8px 4px;height:31px;}
#filtsort .p_footer{border-top: 1px solid #ddd;}
#filtsort .p_right{position:absolute;right:8px;}
#filtsort .p_right a, #filtsort .p_footer a{color:#0033CC;}
.curr_sortfilt{line-height:24px;}
#filt_more{display:none;position:absolute;right:28px;top:2px;padding:4px 0px;width:36px;height:30px; text-align:right;
background:linear-gradient(to right, rgba(238, 238, 238, 0) 0%,  rgba(255,255,255, 1) 100%);}
#filtsort .not_active{background:none;border:1px solid #d0d0d0;cursor:default;}
.r li{margin:0.8em 0 1.2em 0;}
.r li a{display:block}
.p{color:#575757;position:absolute;left:50%;display:block;width:200px;margin-left:-100px;text-align:center;top:14px}
.mid{top:21px;}
.p span{display:block}
.pag{padding:10px 0px;overflow:hidden;position:relative}
.itm{margin:1.5em 0 0;}
.nxt{float:right}
.prv{float:left}
.rel li{font-size:14px;margin-bottom:0.8em}
.rels li{font-size:15px;}
.i{margin-top:0em}
ul{list-style-type:none;padding-left:0;margin-left:0}
li>ul{padding-left:1em}
.ids{margin:0.4em 0;}
.pmids{margin:0.5em 0}
.pmids h3,.pmids span,.ids h3,.ids span{font-weight:normal;display:inline;margin-right:.5em}
.pmids h3 { margin-left: 2.5em;}
.pmids h3::after {content: ':';}
.pmids h3:first-child {margin-left: 0;}
.ids a{color:#0033cc; padding-left: 18px; background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4079699/img/32183) no-repeat scroll 0 1px;}
.inline{display:inline}
.no_b_m{margin-bottom:0}
.ab .no_b_m{font-size:16px;}
.no_t_m{margin-top:0}
.os{float:left;text-indent:-9999em;margin:0;padding:0;height:0}
.meta,.meta h2,.a h3,.rel{font-size:14px}
.meta p{margin:.7em 0}
.ab{margin:1em 0 0.5em;line-height:24px;}
.bk_sctn li{margin:.4em 0}
.w{margin-left:0;}
.wm{padding-left:0;}
.sec_title{margin:20px auto;}
.sec_title span{font-family: "Arial Narrow";font-weight: initial;margin-left: 12px;}
@media print{.but,.f,.fil{display:none}.d .h,.d .r,.a .meta,.a .tab,.a .rel,.hel{max-width:none;}.pag{height:2em;margin:.5em 0}}
@media all and (min-width: 481px) and (orientation:portrait),
all and (min-width: 801px) and (orientation:landscape){
.col{float:left;}
.col_main{ width: 66%;}
.col_supp{width:34%;padding-left:32px;}
.rel{margin:0;border-top:none;padding:0;}
#srch{width:62%;max-width:50em;margin:0 5px;height:32px;position:relative;top:0px;left:0px;}
#logo{position:relative;top:6px;}
#search_but{display:inline;position:relative;height:33px;top:-2px;margin-left:10px;}
#search_tg{display:none;}
#ch{}
.sf{height:48px;}
.header{margin-bottom:24px;}
}
@media all and (max-width: 480px) and (orientation:portrait),
all and (max-width: 800px) and (orientation:landscape){
.w{background-image:url("//static.pubmed.gov/portal/portal3rc.fcgi/4079699/img/4056408");}
.grid{padding: 16px;}
.header{margin-bottom:12px;}
.sf{height:36px;}
#filtsort{position:relative;padding-bottom:16px;}
#filtsort{height:68px;}
#filtsort #filters, #filtsort #sort_options,#filtsort > a {width: 100%;}
#sort_dd {left: 0;top: 40px;}
}
@media all and (min-width: 481px) {
.w{background-image:url("//static.pubmed.gov/portal/portal3rc.fcgi/4079699/img/4056410");}
}
@media
only screen and (-webkit-min-device-pixel-ratio: 2),
only screen and (min--moz-device-pixel-ratio: 2),
only screen and (-o-min-device-pixel-ratio: 2/1),
only screen and (min-device-pixel-ratio: 2),
only screen and (min-resolution: 192dpi),
only screen and (min-resolution: 2dppx) { 
.w{background-image:url("//static.pubmed.gov/portal/portal3rc.fcgi/4079699/img/4056409")}
}
@media
only screen and (min-width: 481px) and (-webkit-min-device-pixel-ratio: 2),
only screen and (min-width: 481px) and (min--moz-device-pixel-ratio: 2),
only screen and (min-width: 481px) and (-o-min-device-pixel-ratio: 2/1),
only screen and (min-width: 481px) and (min-device-pixel-ratio: 2),
only screen and (min-width: 481px) and (min-resolution: 192dpi),
only screen and (min-width: 481px) and (min-resolution: 2dppx) { 
.w{background-image:url("//static.pubmed.gov/portal/portal3rc.fcgi/4079699/img/4056411")}
}