
html, body, div, span, applet, object, iframe,
h1, h2, h3, h4, h5, h6, p, blockquote, pre,
a, abbr, acronym, address, big, cite, code,
del, dfn, em, img, ins, kbd, q, s, samp,
small, strike, strong, sub, sup, tt, var,
b, u, i, center,
dl, dt, dd, ol, ul, li,
fieldset, form, label, legend,
table, caption, tbody, tfoot, thead, tr, th, td,
article, aside, canvas, details, embed, 
figure, figcaption, footer, header, hgroup, 
menu, nav, output, ruby, section, summary,
time, mark, audio, video {
    margin: 0;
    padding: 0;
    border: 0;
    font-size: 100%;
    font: inherit;
    vertical-align: baseline;
}
article, aside, details, figcaption, figure, 
footer, header, hgroup, menu, nav, section {
    display: block;
}
body {
    line-height: 1;
}
ol, ul {
    list-style: none;
}
blockquote, q {
    quotes: none;
}
blockquote:before, blockquote:after,
q:before, q:after {
    content: '';
    content: none;
}
table {
    border-collapse: collapse;
    border-spacing: 0;
}
.grid{ min-width:800px; max-width:1200px; width:100%; clear:both; margin:0 auto; text-align:left;overflow:hidden }
.col { margin-right: 1%; float: left; background-color: #fff; overflow:hidden; }
.last { *zoom:1; *margin-right:0; _margin-right:-6px;  }
.one_col { width: 7.3333%; }
.two_col { width: 15.6664%; }
.three_col { width: 23.9999%; }
.four_col { width: 32.3333%; }
.five_col { width: 40.6666%; }
.six_col { width: 48.9999% }
.seven_col { width: 57.3333%; }
.eight_col { width: 65.6666%; }
.nine_col { width: 73.9999%; }
.ten_col { width: 82.3333%; }
.eleven_col { width: 90.6666%; }
.twelve_col { width: 98.9999%; }
@media screen and (max-width: 1200px) {
	body > .grid > .twelve_col { width: 100%; }
}
body{font:62.5%/1.3846 arial,helvetica,clean,sans-serif;background-color:#ccc}
.grid{font-size: 1.3em}
h1,h2,h3,h4,h5,strong,th,b{font-weight:bold;}
em,i{font-style:italic;}
abbr,acronym{cursor:help;border-bottom:1px dotted #000;}
p,table,pre,fieldset,dl{margin: .6923em 0;}
ul,ol{margin:.6923em 1em;}
blockquote{margin:1.3846em 1em;}
pre,code,kbd,samp,tt {font-family:monospace;font-size:1.2296em;*font-size:1em;} 
ol,ul{margin-left:2em}
ul ul,ol ol,ol ul,ul ol{margin:0 0 0 2em}
ol{list-style:decimal outside}
ul{list-style:disc outside}
ul ul{list-style:circle outside}
ul ul ul{list-style:square outside}
dl dd{margin-left:1em;}
th,td{padding:.2em;border:1px solid #ddd}
th{text-align:center;background-color:#f0f0f0;}
thead{border-bottom:1px solid #eee}
tfoot{border-top:1px solid #eee}
table{border-collapse:collapse;margin:1.3846em 0}
caption{margin-bottom:.5em;text-align:center}
button{cursor:pointer}
h1,.h1{font-size: 1.3846em; line-height:1.5; margin:1em 0 .5em; } 
h2,.h2{font-size: 1.2307em; line-height:1.125; margin:1.125em 0 .5625em;} 
h3,.h3{font-size: 1.0769em; line-height:1.2857; margin:1.2856em 0 .6428em; } 
h4,h5,h6,h3.inline{font-size: 1em; margin:1.3846em 0 .6923em; } 
h5,.h5{font-style:italic;font-weight:normal;}
h4,.h4{color:#59331f;}
h3,.h3{color:#724128;}
h2,.h2{color:#985735;}
h1,.h1{color:#000;}
h3.inline,h4.inline,h5.inline,h6.inline{display:inline;float:left;margin:0;padding-right:.3em}
.whole_rhythm {margin: 1.3846em 0} 
.half_rhythm {margin: .6923em 0} 
.no_top_margin{margin-top:0}
.no_bottom_margin{margin-bottom:0}
.no_margin{margin:0}
.content a{color:#2f4a8b}
.content a:hover,.content a:active{color:#985735}
.content a:visited{color:#642a8f}
img{border:0}
.inline_list,.inline_list_right{list-style-type:none;margin:0;padding:0}
.inline_list li{display:inline;margin-right:.3em}     
.inline_list_right li{display:inline;margin-left:.4em;}
.column_list{list-style-type:none;margin:0;padding:0}
.column_list li{float:left;width:8em}
.offscreen{text-indent:-9999px}
.offscreen_noflow{float:left;text-indent:-9999em;_display:block;margin:0;padding:0;height:0;}
.left{float:left}
.right{float:right}
.align_right{text-align:right}
.hidden{display:none}
.nowrap{white-space:nowrap}
.noborder{border:0}
.no_max_width{max-width:none}
.inline_block{display:-moz-inline-box;display:inline-block;*display:inline;zoom:1;}
.clearfix:before,.clearfix:after{content:"";display:table}.clearfix:after{clear:both}.clearfix{zoom:1}
.small,sup,sub{font-size:.8461em;} 
.small sup,.small sub{font-size:1em}
.small{line-height:1.6363em}
sup,sub{position:relative;vertical-align:baseline}
sup{top:-.5em}
sub{top:.25em}
.shadow {-webkit-box-shadow: 0.4em 0.4em 0.5em rgba(0,0,0,.3);-moz-box-shadow: 0.4em 0.4em 0.5em rgba(0,0,0,.3);box-shadow: 0.4em 0.4em 0.5em rgba(0,0,0,.3)}
.iconblock{overflow:hidden}
.icnblk_img{text-decoration:none;float:left;margin-right:1em;cursor:pointer}
.icnblk_img_right { float: right; margin-right: 0; margin-left: 1em;}
.icnblk_cntnt{display:table-cell;vertical-align:top;*zoom:1}
.icnblk_cntnt h1,.icnblk_cntnt h2,.icnblk_cntnt h3,.icnblk_cntnt h4{margin:0 0 .6923em}
.tgt_light{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/2846531) no-repeat 100% -1%;padding-right:17px;margin-right: 3px}
.tgt_light:active{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/2846531) no-repeat 100% 12%}
.tgt_dark{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/2846531) no-repeat 100% 43.5%;padding-right:17px;margin-right:3px}
.tgt_dark:active{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/2846531) no-repeat 100% 25%}
.tgt_light_up{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/2846531) no-repeat 100% 56%;padding-right:17px;margin-right:3px}
.tgt_light_up:active{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/2846531) no-repeat 100% 69%}
.tgt_dark_up{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/2846531) no-repeat 100% 100%;padding-right:17px;margin-right:3px}
.tgt_dark_up:active{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/2846531) no-repeat 100% 83%}
.tabPopper{top:0;left:0;display:none;background-color:#fff;padding:.2em;margin-top:3px;*padding-bottom:1em;box-shadow:.4em .4em .5em #999;-webkit-box-shadow:.4em .4em .5em #999;-moz-box-shadow:.4em .4em .5em #999;border:1px solid #ccc;border-bottom:1px solid #666\0;border-right:1px solid #666\0;}
.tabPopperCover{position:absolute;top:0px;left:0px;height:1px;background-color:#FFA600;overflow:hidden}
.tabPopper fieldset{border:0;padding:0;margin:4px 10px}
.tabPopper fieldset ul,.tabPopper fieldset dl{border-top:1px solid #ddd;padding-top:3px}
.tabPopper fieldset dl{margin:0 0 6px 0}
.tabPopper fieldset input{position:relative;top:1px}
#maincontent .content{ padding:0 0 2em 1.231em; }
#maincontent .content .content { padding-left: 0; }
.title_and_pager{margin:.9em 0 1.3em}
.results_settings,.title_and_pager,.rprt{zoom:1}
.nlm{font-size:.692em;line-height:1.2;margin-top:.2em}
.nlm a{color:#555}
.pmlogo{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/2318832) no-repeat scroll left top;display:block;height:32px;width:110px;text-indent:-9999px}
noscript p.nojs {
	background: #ffb url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/67327) no-repeat 5px center;
	padding: 4px;
	padding-left: 28px;
	margin:0;	
}
.header{background:#d5d5d5 url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/2375536) repeat-x scroll left bottom; position: relative;margin-bottom: 1.231em;z-index:20 }
.header a{text-decoration:none}
.header a:hover{text-decoration:underline}
.search{margin:0 0 0 13.539em; padding:1.2em 0 .7em}
.search_form{*zoom:1}
.search_form select,.search_form .jig-ncbiclearbutton-wrap,.search_form button{margin-right:.2em;font-family:arial,helvetica,sans-serif;}
.search_form select{font-size: 1.077em; width:8.5em;margin-right:.3em;*vertical-align: middle; position: relative; bottom: 1px;}
.search_form input{font-size: 1.1543em; width:48%;display:inline-block;_width:100%}
.search_form div.nowrap {*height: 100%; }
.search_form button.nowrap {*vertical-align: middle; }
.search_form div.nowrap div.nowrap {*height: 100%; *vertical-align: middle; }
.search_form .nowrap{display:inline;*zoom:1}
.searchlinks{margin:.2em 0 0 9.6em;_zoom:1}
.searchlinks li{margin-right:1.2em;zoom:1}
.searchlinks .help{position:absolute;right:1em;margin-right:0;_margin-top:-.1em}
.searchlinks .hidden{display:none}
.searchlinks .visible{display:inline}
.search_form .wrap{position:relative;display:inline;_width:70%}
#cl{position:absolute;right:8px;top:-3px;top:-12px\9;*top:5px}
.search_form button{border:0 none;cursor:pointer;overflow:visible;width:auto;background-color:#ddd;padding:.2em .4em;*padding:.2em .6em;_padding:.2em .4em;margin:0 .2em;*margin:0 .3em;*height:2em; -moz-border-radius:5px;-webkit-border-radius:5px;border-radius:5px;text-shadow:.1em .1em .1em rgba(0,0,0,.5);-moz-box-shadow:.1em .1em .1em rgba(0,0,0,.5);-webkit-box-shadow:.1em .1em .1em rgba(0,0,0,.5);box-shadow:.1em .1em .1em rgba(0,0,0,.5)}
.search_form button.button_search{background-color:#47a;font-weight:bold;color:#fff;*margin-left:.5em;font-size:inherit;}
.search_form button.button_search:active{background-color:#4c96df}
.search_form button.button_preview{background-color:#A64D48;font-weight:bold;color:#fff}
.search_form button.button_preview:active{background-color:#F27069}
.search_form input:focus{-moz-box-shadow:0 0 .3em rgba(211,186,44,.8)}
.search_form .jig-ncbiclearbutton-wrap { width: 65%; *display: inline; border:1px solid #999; }
.search_form .jig-ncbiclearbutton-wrap input { width: 100%; *width: 50%; }
.search_form .jig-ncbiclearbutton-wrap a.reset { margin-left: 0; top: 50%; margin-top: -7px; }
.rss_icon{position:relative;top:3px;margin-right:.3em}
.rss_menu{z-index:1001;display:none;}
.rss_menu legend{font-weight:bold;margin:2px 0 0 3px}
.rss_menu ul{margin:0;padding:0;list-style-type:none;padding-top:5px}
.rss_menu ul li{margin-bottom:.4em}
.rss_menu span,.rss_menu label{margin-right:.5em}
.rss_menu ul input{top:0}
.rss_menu dd{margin-left:0;margin-bottom:1em}
.rss_menu #rss_name{width:15em}
.rss_menu button{margin-top:.5em}
.rss_menu label{display:block}
.db_logo{background:transparent url() no-repeat scroll left top;display:block;height:36px;width:100px;text-indent:-9999px}
.res_logo{width:11.539em;left:1.231em;padding-top:.4em;position:absolute}
.res_logo h1{font-weight:normal;margin:0}
.long{padding:.5em 0}
.long h1{line-height:1.15}
.res_logo h1 a{color:#333;display:block;padding:.3em 0;text-shadow:1px 1px 1px rgba(240,240,240,.9)}
.res_tagline{display:none}
.res_logo h1 a,.res_logo h1 a:hover,.res_logo h1 a:visited{text-decoration:none}
h1.img_logo{margin:0}
h1.img_logo a{padding:0}
.send_to .hint { }
.display_settings, .send_to { margin: 0 0 1.1em 0; }
.display_settings li a { color: black; text-decoration: none; }
h4.content_header { margin-right: .2em;}
h4.send_to { float: right; _white-space: nowrap; }
.send_to .column_list { width: 20em; }
.disp_settings .column_list li { float: none; width: 9.5em; }
.sort .column_list li{width:13.5em;}
.format, .sort, .items { float: left; }
.format legend, .sort legend, .items legend, .send_to legend {font-weight:bold;margin: 2px 0 0 3px;}
.disp_settings { margin-left: 1em; _width:42em; }
div.results_settings{
    position:relative;  
}
.one_setting .disp_settings { _width:21em; }
.two_settings .disp_settings { _width:31em; }
.send_to { _width: 9em;}
.disp_settings button.button_apply { margin: 11em .5em .5em .8em;  }
.send_to .submenu { border-top: 1px solid #ddd; padding: 1em; margin:0; }
.send_to .submenu ul { margin: 0; padding:0; list-style-type:none; }
.send_to .submenu ul li { margin-bottom: .4em; }
.send_to .submenu ul li label { display: block; }
.send_to .hint { margin: .5em 0; }
.email_alert { background-color: #fcc; display: block;}
p#email_alert { display: none; }
p#email_alert.email_alert { background-color: #fcc; display: block;  }
div#send_to_menu , div#send_to_menu2 { width:300px; }
.send_to .column_list li { width: 9.5em; }
.send_to .mail ul li span label { display: inline;}
.browsercheck .warn {
    color: #000;
}
.browsercheck .error {
    color: #000;
}
.success, .error, .warn, .info, .suggest, .hi_warn {
    background-image: url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/3380404);
    padding-left: 1.7em;
    background-repeat: no-repeat;
    background-color: transparent;
    margin-bottom:.5em
}
.success {
    background-position: 0 0;
}
.warn {
    background-position: 0 -16px;
}
.hi_warn {
    background-position: 0 -16px;
    font-weight: bold;
}
.suggest {
    background-position: 0 -32px;
}
.info {
    background-position: 0 -48px;
}
.error {
    background-position: 0 -64px;
}
div.success_msg, div.warn_msg, div.error_msg { padding: .4em; margin: .5em; color: black; font-family: helvetica, arial, verdana, sans-serif; }
div.success_msg img, div.warn_msg img, div.error_msg img { position: relative; top: .15em; margin-left: .2em; }
div.success_msg { border: 1px solid #6c6; background-color: #cfc; }
div.warn_msg { border: 1px solid #e3d21c; background-color: #ffffef; }
div.error_msg { border: 1px solid #f88; background-color: #fdd; }
div.messagearea {
    margin:0; 
    padding: 0; 
    border-bottom: solid 1px #888; 
    clear:both;
} 
#messagearea.empty {border: none; clear:both;} 
ul.messages {
    font-family: Arial;
    margin: 0; 
    padding: 0; 
    list-style-type:none;
    list-style-image:none;
}
ul.messages li {
    margin:0.22em 0 0.22em;
    padding: 0.25em;
    background-repeat: no-repeat;
    background-color: transparent; 
    background-position: 0.5em 0.3em;
    position: relative; 
}
ul.messages li .icon{ 
    background-image: url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/3380404); background-repeat: no-repeat; height: 16px; width: 16px; display: inline-block; margin-right: 4px;}
    
ul.messages li.success .icon {background-position: 0 0;}
ul.messages li.warn .icon {background-position: 0 -16px;}
ul.messages li.hi_warn .icon {background-position: 0 -16px;}
ul.messages li.suggest .icon {background-position: 0 -32px;}
ul.messages li.info .icon {background-position: 0 -48px;}
ul.messages li.error .icon {background-position: 0 -64px;}
ul.messages li.hi_warn { font-weight: bold;}
div#messagearea ul.messages li.hi_warn { margin: 2.5em 0; }
ul.messages li.hi_warn em.detail{
    font-weight: normal;
    font-style: normal;
    padding-left: 0.5em;
}
.portlet { border-top: .4em solid #97b0c8; padding-top: .461em; margin: .769em 0 2.154em 0; overflow: visible; line-height: 1.231em; zoom:1; }
.portlet h1, .portlet h2, .portlet h3, .portlet h4, .portlet h5, .portlet h6 {color: #985735; font-weight: bold; display: inline;  }
.portlet .whatsthis {color: #14376c; white-space: nowrap; margin-left: .3em;}
.portlet ul { margin: 0; padding: 0; }
.portlet ul li { list-style-type: none; margin-top: .461em; border-bottom: 1px dotted #CCC; padding-bottom: 1px; position: relative; overflow: visible; zoom:1;  }
.portlet .portlet_list li { border-bottom: 0; }
.portlet ul li a { font-weight: normal; color: #14376c; text-decoration: none; }
.portlet ul li a:hover,.portlet ul li a:active{border-bottom:0}
.portlet ul a { _display: block; _float: left; _clear: left; }
.portlet .seemore { display: block; text-align: right; color: #14376c; font-size: .923em; text-decoration: none; margin-top: .8em; }
.portlet .portlet_section_header { text-decoration: none; font-weight: bold; color: #000; border-bottom:0 } 
.portlet li.two_line { height: 2.461em; height\0: 2.361em; overflow: hidden; }
.portlet .two_line a { max-height: 2.453em; overflow: hidden; display: block; }
.portlet .long_info, .portlet p, .portlet .two_line .source, .portlet .one_line_source, .portlet_content .image .desc { color: #777;}
.portlet .two_line .source, .portlet .one_line_source { white-space: nowrap; position: absolute; right: 0; background-color: white; padding-left: .3em; }
.portlet .two_line .source { top: 1.231em; }
.portlet .two_line .tertiary { font-size: .769em; color: #777; position: absolute; right:0; background-color: white; padding: .1em 0 0 .3em; top: 1.6em; top\0: 1.5em; }
.portlet .portlet_content p { margin: .8em 0; }
.portlet .buttonwrap { float: left; position: relative; top: -.1em; overflow: visible; }
.portlet .invert { color: #fff; background-color: #14376c; padding: 0 .2em; }
.portlet .tertiary { color: #777; text-align: right; line-height: 1.4em; position: relative; top: .1em; }
.portlet_content { position: relative; margin: 0; }
.portlet_content textarea { margin: 0 0 .9em; }
.portlet_content img { margin: .3em 1.4em .7em 0;}
.portlet_content .image { display: block; overflow: auto; overflow:hidden\0; }
.portlet_content .image .img_link { float: left; }
.portlet_shutter { background: url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/32197) no-repeat scroll left top;  display: block; float: right; width: 15px; height: 15px; position: absolute; top: -.2em; margin-left: .6em; right: 0; }
.shutter_closed { background-position: left bottom; }
.portlet .related li { border-bottom: 0; }
.portlet .right { text-align: right; }
.ra_qry, .ra_rcd { padding-left: 2em; }
.ra_qry { background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/32182) no-repeat scroll 0 1px; }
.ra_rcd { background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/3759989/img/32183) no-repeat scroll 0 1px; }
.sensor{border:1px solid #C8DDEB;background-color:#F7F9FB;padding:0 1em 1em;margin:1em 0}
.sensor .sensor_head { margin-bottom: 0; position: relative}
.sensor .sensor_head h3 { font-weight: normal; }
.sensor h3,.sensor h4,.sensor h5,.sensor h6{margin:.6923em 0 0}
.sensor .sensor_content{margin-bottom:1.1em}
.sensor p{margin:0}
.sensor .portlet_shutter { display: none; }
.no_p_margins{margin:0}
.portlet_head{margin-bottom:.461em;position: relative}
.portlet_title,.sensor_title{margin-right: 2em}
.portlet_title h3 { line-height: inherit; }
#ResultsHighlighter {  
    margin: .5em 0 1.0em;
    padding: .2em 0 .3em .4em;   
    background-color:#ffffdd;
    }
#ResultsHighlighter ul { 
    list-style-type: none; 
    padding: 0 1em; 
    margin: .4em 0 0 .3em;
}
li.highlight { margin: .2em 0em; }
 
li.highlight span.cit { 
    margin: .1em 0 .1em .5em; 
    color: #117;
    font-size: .9em;
} 
li.highlight span.cit abbr {
    border: none;
    font-style:italic;
}
#ResultsHighlighter h2, #CSResultsHeader h2 { 
    color: #444; 
    font-size: 1em;
    padding-bottom: .2em;
    margin: 0 auto;
}
#ResultsHighlighter span.all {
    float:right;
    clear:left;    
    padding-right:1em; 
}
#CSResultsHeader {  
    font-size: .9em; 
    margin: .5em 0 0 0;
    padding: .2em 0 .3em .4em;  
}
h2.result_count { display:inline; white-space:nowrap;}
.result_sel { margin-left: 1em;white-space:nowrap;}
.clip_actions { margin-bottom: 1.3em; }
.clip_action { color: #D2692B;text-decoration: none; border-bottom: 1px dotted #D2692B; margin-left: 1em; white-space:nowrap;}
.rprt {
	overflow: hidden;
	_overflow: none;
	margin: 0.5em 0 1.5em 0;
	padding: 0; 
	*margin-bottom: 0.9em;
	zoom: 1;
	display: block;
	clear: both;
	min-height: 40px;
	height: auto !important;
	height: 40px; }
.rprt .rprtnum {
	display: inline;
	float: left;
	overflow: visible; }
.rprt .rprtnum input {
	display: block;
	float: none;
	margin-left: 0; }
.rprt .rprtnum span {
	display: block;
	clear: both;
	margin-right: 5px;
	margin-left: 1px; 
	*margin-left: 4px; }
.rprt .rslt { margin-left: 28px; *height: 1%; *margin-left: 0; }
.rprt .rsltimg { float: left; }
.rprt .rsltimg_right { float: right; margin-right: 0; margin-left: 1em;}
.rprt .rsltimg img {
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