div#besetsel-form h3 {
  color: white;
}
div.besetsel-body {
  margin-left: 1em;
}
div#besetsel-form div {
  margin-bottom: .5em;
}
div#besetsel-form a {
  color:white;
}
div#besetsel-form a:hover {
  background-color: #666;
}
.sidecontentpullout {
	background-color: #c00;
	color: white;
	padding: 4px 3px;
	-moz-border-radius-bottomleft: 1em;
	-moz-border-radius-topleft: 1em;
	-webkit-border-bottom-left-radius: 1em;
	-webkit-border-top-left-radius: 1em;
	border-bottom-left-radius: 1em;
	border-top-left-radius: 1em;
	font-size: 1.2em;
	opacity: 1 !important;
}
.sidecontentpullout:hover {
	background-color: #444444;
	color: white;
	opacity: 1 !important;
}
.sidecontent {
    font-size: 1.2em;
	background-color: black;
	color: white;
	-moz-border-radius-bottomleft: 1em;
	-webkit-border-bottom-left-radius: 1em;
	border-bottom-left-radius: 1em;
	zoom: 1;
	z-index: 10000 !important;
}
.sidecontent > div > div {
	padding-left: 10px;
	padding-right: 40px;
}
.sidecontent h2 { color: white; }
.sidecontent a { color: white; display: block; margin: 0; padding: 2px 5px;}
.sidecontent a:hover { background-color: #666;}
.sidecontent, .sidecontentpullout { position: fixed !important; }
.sctable td { border: none; padding-right: 5px;}
body{font:62.5%/1.3846 arial,helvetica,clean,sans-serif;background-color:#ccc;margin:0}
.grid{font-size: 1.3em}
img{border:0}
abbr,acronym{cursor:help;border-bottom:1px dotted #000;}
blockquote{margin:1.3846em 1em;}
p,table,pre,fieldset,dl{margin: 0.6923em 0;}
ol,ul{margin: 0.6923em 1em 0.6923em inherit}
dl dd{margin-left:1em;}
table{border-collapse:collapse;margin:1.3846em 0;}
thead{border-bottom:1px solid #eee;}
tfoot{border-top:1px solid #eee;}
th{text-align:center;background-color:#f0f0f0;}
th,td{padding:0.2em;border:1px solid #ddd;}
caption{margin-bottom:.5em;text-align:center;}
fieldset {border: 0;}
button{cursor:pointer;}
input,button,textarea{margin:2px;}
input[type="checkbox"] {margin: 3px 3px 3px 4px;}
textarea {font-family: monospace; font-size: 1.2296em; *font-size:1em; vertical-align:baseline;}
h1,.h1{font-size: 1.3846em; line-height:1.5; margin:1em 0 .5em; } 
h2,.h2{font-size: 1.2307em; line-height:1.125; margin:1.125em 0 .5625em;} 
h3,.h3{font-size: 1.0769em; line-height:1.2857; margin:1.2856em 0 .6428em; } 
h4,h5,h6,h3.inline{font-size: 1em; margin:1.3846em 0 .6923em; } 
h5,.h5{font-style:italic;font-weight:normal;}
h6, .h6 {font-weight: normal;}
h4,.h4{color:#59331f;}
h3,.h3{color:#724128;}
h2,.h2{color:#985735;}
h1,.h1{color:#000;}
h3.inline,h4.inline,h5.inline,h6.inline{display:inline;float:left;margin:0 0 -0.125em;padding-right:.3em}
.whole_rhythm {margin: 1.3846em 0} 
.half_rhythm {margin: .6923em 0} 
.no_top_margin{margin-top:0}
.no_bottom_margin{margin-bottom:0}
.no_margin{margin:0}
.content a{color:#2f4a8b}
.content a:hover,.content a:active{color:#985735}
.content a:visited{color:#642a8f}
.inline_list,.inline_list_right{list-style-type:none;margin:0;padding:0}
.inline_list li{display:inline;margin-right:.3em}     
.inline_list_right li{display:inline;margin-left:.4em;}
.column_list{list-style-type:none;margin:0;padding:0}
.column_list li{float:left;width:8em}
.offscreen{text-indent:-9999px}
.offscreen_noflow{float:left;text-indent:-9999em;_display:block;margin:0;padding:0;height:0;}
.left{float:left}
.right{float:right}
.align_right{text-align:right}
.hidden{display:none}
.nowrap{white-space:nowrap}
.noborder{border:0}
body .no_max_width{max-width:none;overflow:auto}
.inline_block{display:-moz-inline-box;display:inline-block;*display:inline;zoom:1;}
.clearfix:before,.clearfix:after{content:"";display:table}.clearfix:after{clear:both}.clearfix{zoom:1}
.small,sup,sub{font-size:.8461em; line-height: 1.6363em;} 
.small sup,.small sub{font-size:1em}
sup,sub{position:relative;vertical-align:baseline;}
sup{top:-.5em}
sub{top:.25em}
.shadow {-webkit-box-shadow: 0.4em 0.4em 0.5em rgba(0,0,0,.3);-moz-box-shadow: 0.4em 0.4em 0.5em rgba(0,0,0,.3);box-shadow: 0.4em 0.4em 0.5em rgba(0,0,0,.3)}
.iconblock{overflow:hidden}
.icnblk_img{text-decoration:none;float:left;margin-right:1em;cursor:pointer}
.icnblk_img_right { float: right; margin-right: 0; margin-left: 1em;}
.icnblk_cntnt{display:table-cell;vertical-align:top;*zoom:1}
.icnblk_cntnt h1,.icnblk_cntnt h2,.icnblk_cntnt h3,.icnblk_cntnt h4{margin:0 0 .6923em}
.grid{ min-width:800px; max-width:1200px; width:100%; clear:both; margin:0 auto; text-align:left;overflow:hidden }
.col { margin-right: 1%; float: left; background-color: #fff; overflow:hidden; }
.last { *zoom:1; *margin-right:0; _margin-right:-6px;  }
.col.last {float:right;}
.one_col { width: 7.3333%; }
.two_col { width: 15.6664%; }
.three_col { width: 23.9999%; }
.four_col { width: 32.3333%; }
.five_col { width: 40.6666%; }
.six_col { width: 48.9999% }
.seven_col { width: 57.3333%; }
.eight_col { width: 65.6666%; }
.nine_col { width: 73.9999%; }
.ten_col { width: 82.3333%; }
.eleven_col { width: 90.6666%; }
.twelve_col { width: 98.9999%; }
@media screen and (max-width: 1200px) {
	body > .grid > .twelve_col { width: 100%; }
}
h1.res_name a.imglogo {
    background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/251741) no-repeat scroll 0% 0%;
    display: block;
    height: 45px;
    text-indent: -9999px;
    width: 165px;
}
body h1{font-size: 1.3846em; line-height:1.5; margin:1em 0 .5em; } 
body h2{font-size: 1.2307em; line-height:1.125; margin:1.125em 0 .5625em;} 
body h3{font-size: 1.0769em; line-height:1.2857; margin:1.2856em 0 .6428em; } 
body h4,body h5,body h6,body h3.inline{font-size: 1em; margin:1.3846em 0 .6923em; } 
body h5{font-style:italic;font-weight:normal;}
body h4{color:#59331f;}
body h3{color:#724128;}
body h2{color:#985735;}
body h1{color:#000;}
.paf-font-fix { font-size: 0.909em; }
.page > .header { position: relative; } 
.page > .header h1 { font-size: 160%; } 
.footer > div { border: solid 1px transparent; } 
div.messagearea {
    margin:0;
    padding: 0;
    clear:both;
}
div.browsername {
    background-color: #FFF;
    padding-left: 0.5em;
    }
#messagearea.empty {
    border: none;
    clear: both;
}
div#messagearea ul.messages li.hi_warn { margin: 2.5em 0; }
ul.messages {
    font-family: arial, helvetica, sans-serif;
    margin: 0;
    padding: 0;
    list-style-type: none;
    list-style-image: none;
}
ul.messages li {
    margin: 0.22em 0 0.22em;
    padding: 0.25em;
    background: transparent no-repeat 0.5em 0.3em;
    position: relative;
}
ul.messages li .icon, ul.messages li.icon{ 
    background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/3797312) no-repeat; 
    display: block; 
    margin-right: 4px;
    padding-left: 16px;
}
ul.messages li span.icon {
    background: #fff;
    padding-left: .5em;
    padding-top: .35em;
    margin-top: -.5em;
}
ul.messages li.success .icon, ul.messages li.success.icon {
    background-position: 0 0;
}
ul.messages li.warn .icon, ul.messages li.hi_warn .icon, ul.messages li.warn.icon, ul.messages li.hi_warn.icon {
    background-position: -17px 0;
}
ul.messages li.suggest .icon, ul.messages li.suggest.icon {
    background-position: -34px 0;
}
ul.messages li.info .icon, ul.messages li.info.icon {
    background-position: -51px 0;
}
ul.messages li.error .icon, ul.messages li.error.icon {
    background-position: -68px 0;
}
ul.messages li.hi_warn em.detail{
    font-weight: normal;
    font-style: normal;
    padding-left: 1.7em;
}
ul.messages li.hi_warn {
    font-weight: bold;
}
.success, .error, .warn, .info, .suggest, .hi_warn {
    background-image: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/3797312);
    padding-left: 17px;
    background-repeat: no-repeat;
    background-color: transparent;
    margin-bottom:.5em
}
.success {
    background-position: 0 0;
}
.warn {
    background-position: -17px 0;
}
.hi_warn {
    background-position: -17px 0;
    font-weight: bold;
}
.suggest {
    background-position: -34px 0;
}
.info {
    background-position: -51px 0;
}
.error {
    background-position: -68px 0;
}
div.ui-ncbiexpander-simple {border:none;}
#maincontent h2 {color:#000;}
.nav_and_browser {margin-bottom: 1.231em;}
div.dbheader div.headerimage { background-repeat: repeat-y; background-image: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/3866156); }
.col1 {padding-left:1em;}
.clear_fix {clear:both; padding:0; margin:0; height:0;}
.margin_0 {margin:0;}
.margin_t0 {margin-top:0;}
.margin_b0 {margin-bottom:0}
.margin_b1 {margin-bottom:1em;}
.supplemental { width:100%;}
.serif_font {font-family:"Georgia", serif;}
#messagearea {margin-left:1em; margin-right:1em;}
.static #maincontent .col1, .all_submitters #maincontent .col1, .resource-home-page #maincontent .col1  {padding-right:1em;}
.ui-ncbigrid-header, .ui-ncbigrid-header-wrapper {max-width:100%; width:100% !important;}
table.jig-ncbigrid {border-collapse: collapse;}
#sec_allele h3 {color:#724128;}
#supplemental div#HTDisplay div.action a, #HTDisplay .HTOn{font-size:.9em;}
#HTDisplay .HTOff {font-size:.85em;}
#clinvar_debug {opacity:.5; margin-bottom:1em;}
#clinvar_debug:hover {opacity:1;}
.rcv_header {white-space:normal; float:left; margin-right:.5em;}
dd ul {margin-top:0; list-style-type:disc; margin-left:1.13em;} 
dd ul li {margin-bottom:.5em;}
dd ul.dd_list {list-style-type:none; margin:0; padding-left:12px; border-left:1px solid #C8DDEB;}
dd ul.dd_list li {padding:0; margin:0;}
#maincontent dd {max-width:65%;}
#maincontent #mainrevstatandid dt {width:12em;}
#maincontent #main_box dd {min-width:50%;}
#maincontent dd ul.dd_listregu, #maincontent dd.hard_break div div ul.dd_listregu {list-style-position: inside; margin:0; padding: 0;}
#maincontent dd ul.dd_listregu li, #maincontent dd.hard_break div div ul.dd_listregu li { margin:0; padding:0; color: #C8DDEB;}
#maincontent dd ul.dd_listregu li span.ddulregtext, #maincontent dd.hard_break div div ul.dd_listregu li span.ddulregtext  {color: #000;}
#maincontent h3.mainsectionheading {border-bottom: 1px solid #724128; font-size:1.343em;}
#main_box dl.details_large.details dt {}
dl.details dd span.dlhelp {margin-left:.5em;}
#maincontent span.dlhelp.helpicon a {text-indent: -9999px; background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/4087875) no-repeat left top; display:inline-block; height: 20px; width: 20px; background-size:17px 17px;}
#maincontent a.popperlink {background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/4093781) no-repeat right top; display:inline-block; background-size:17px 17px; padding-right:20px;}
.resource-home-page .container #maincontent h2 {color: #985735;}
.rating span.active {background-image:url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/3892121); background-size:17px; background-repeat: no-repeat; width: 27px; height: 23px; display: inline-block;}
.rating span.inactive {background-image:url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/3892122); background-size:17px; background-repeat: no-repeat; width: 27px; height: 23px; display: inline-block;}
.rev_stat_text {height: 23px; display:inline-block; vertical-align: top; line-height:19px;}
.hide {position: absolute !important; top: -9999px !important; left: -9999px !important;}
.hard_break {white-space: pre-wrap;  white-space: -moz-pre-wrap;  
             white-space: -pre-wrap;  white-space: -o-pre-wrap;  
             word-wrap: break-word;  -ms-word-break: break-all; }
li.invalid_hgvs, li.invalid_hgvs a, li.invalid_hgvs a:visited {color:#777; text-decoration:none;}
.nodatalighten {color: #777;}
.usa-label {
  background-color: #0f74ae;
  border-radius: 3px;
  color: white;
  font-size: 1em;
  margin-right: 0.5em;
  padding: 0.2em 0.5em;
  text-transform: None;
  white-space: nowrap;
}
ul.bottom-citations-list {
    margin-bottom: 0;
}
.usa-label a:link{
color: white;
}
.usa-label a:visited{
color: white;
}
noscript p.nojs {
	background: #ffb url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/67327) no-repeat 5px center;
	padding: 4px;
	padding-left: 28px;
	margin:0;	
}
.dbheader { height: 10.769em; overflow: hidden; border: 1px solid #000; }
.dbheader .headerimage { background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/32161) no-repeat 58% 52%; background-size: 100% 100%; height: 100%; width: 33%; float: left; _left:0px; _position:absolute; }
.dbheader .headerintro { background-color: #141927; border-left: 1px solid #000; height: 100%; margin-left: 33%;  }
.dbheader .headerintro h1 { color: #f7f7f7; font-size: 1.846em; font-weight: bold; background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/32161) repeat-y 0 0; margin:0; padding: .333em .75em .333em .75em; line-height: 1em; }
.headerintro .dbdescription { color: #f7f7f7; font-size: 1.077em; padding: 1.285em; }
.dbheaderad { height: 14.2em; margin: 1.6em 1.6em 2.8em; overflow: hidden; }
.dbheaderad .aboutdb { width: 66%; border: 1px solid #000; height: 14em; float: left; _height: 100%; }
.dbheaderad .aboutdb .headerimage { background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/32161) no-repeat 20% 52%; height: 100%; width: 17%; float: left; }
.dbheaderad .aboutdb .headerintro { background-color: #141927; border-left: 1px solid #000; height: 100%; margin-left: 17%; }
.dbheaderad .aboutdb .headerintro h1 { color: #f7f7f7; font-weight: bold; background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/32161) repeat-y 0 0; margin:0; padding: .333em .75em .75em; }
.dbheaderad .aux { color: #f7f7f7; border: 1px solid #000; margin:0; width: 31%; height: 7.43em; margin-left: 68%; font-size: 1.4em; padding: 1.285em; zoom:1; *width: 27.2%; _width: 100%; _height: 100%; }
.tier { margin: 1.6em 0 2.8em; overflow: auto; zoom: 1;}
.tier .onecol { width: 32%; margin-right: 2%; float: left; } 
.tier .lastcol { margin-right: 0; *width: 31.5%; }
.img-credit { color: #777; text-align: right; margin: 0 1.6em -1.5em; }
.firsttier_portlet h1, .firsttier_portlet h2, .firsttier_portlet h3, .firsttier_portlet h4, .firsttier_portlet h5, .firsttier_portlet h6 { color: #985735; background-color: #fafafa; border-top: .2em solid #f7f7f7; border-bottom: .2em solid #f7f7f7; padding-top: .3em; padding-bottom: .3em; margin:0; }
.firsttier_portlet .portlet_head { margin: 0; }
.firsttier_portlet .portlet_content ul { margin: 0; padding: 0; }
.firsttier_portlet .portlet_content ul li { padding-top: .4em; border-bottom: 1px dotted #ccc; padding-bottom: .3em; list-style-type: none; }
.firsttier_portlet .portlet_content ul li a { color: #14376c; }
div.page div.header { margin-bottom: 0;}
.header{background:#d5d5d5 url(//static.pubmed.gov/portal/portal3rc.fcgi/4188096/img/2375536) repeat-x scroll left bottom; position: relative;margin-bottom: 1.231em;z-index:20 }
.header a{text-decoration:none}
.header a:hover{text-decoration:underline}
.search{margin:0 0 0 13.539em; padding:1.2em 0 .7em}
.search_form{*zoom:1}
.search_form select,.search_form .ui-ncbiclearbutton-wrap,.search_form button{margin-right:.2em;font-family:arial,helvetica,sans-serif;}
.search_form select{font-size: 1.077em; width:8.5em;margin-right:.3em;*vertical-align: middle; position: relative; bottom: 1px;}
.search_form select optgroup {font-style: normal; color: #555; padding-left: 0.2em;} 
.search_form select optgroup option {color: #000}
.search_form input{font-size: 1.1543em; width:48%;display:inline-block;_width:100%}
.search_form div.nowrap {*height: 100%; }
.search_form button.nowrap {*vertical-align: middle; }
.search_form div.nowrap div.nowrap {*height: 100%; *vertical-align: middle; }
.search_form .nowrap{display:inline;*zoom:1}
.searchlinks{margin:.2em 0 0 9.6em;_zoom:1}
.searchlinks li{margin-right:1.2em;zoom:1}
.searchlinks .help{position:absolute;right:1em;margin-right:0;_margin-top:-.1em}
.searchlinks .hidden{display:none}
.searchlinks .visible{display:inline}
.search_form .wrap{position:relative;display:inline;_width:70%}
#cl{position:absolute;right:8px;top:-3px;top:-12px\9;*top:5px}
.search_form button{border:0 none;cursor:pointer;overflow:visible;width:auto;background-color:#ddd;padding:.2em .4em;*padding:.2em .6em;_padding:.2em .4em;margin:0 .2em;*margin:0 .3em;*height:2em; -moz-border-radius:5px;-webkit-border-radius:5px;border-radius:5px;text-shadow:.1em .1em .1em rgba(0,0,0,.5);-moz-box-shadow:.1em .1em .1em rgba(0,0,0,.5);-webkit-box-shadow:.1em .1em .1em rgba(0,0,0,.5);box-shadow:.1em .1em .1em rgba(0,0,0,.5)}
.search_form button.button_search{background-color:#47a;font-weight:bold;color:#fff;*margin-left:.5em;font-size:inherit;}
.search_form button.button_search:active{background-color:#4c96df}
.search_form button.button_preview{background-color:#A64D48;font-weight:bold;color:#fff}
.search_form button.button_preview:active{background-color:#F27069}
.search_form input:focus{-moz-box-shadow:0 0 .3em rgba(211,186,44,.8)}
.search_form .ui-ncbiclearbutton-wrap { width: 64%; *display: inline; border:1px solid #999; }
.search_form .ui-ncbiclearbutton-wrap input { width: 100%; *width: 50%; }
.search_form .ui-ncbiclearbutton-wrap a.reset { margin-left: 0; top: 50%; margin-top: -7px; }
.rss_icon{position:relative;top:3px;margin-right:.3em}
.rss_menu{z-index:1001;display:none;}
.rss_menu legend{font-weight:bold;margin:2px 0 0 3px}
.rss_menu ul{margin:0;padding:0;list-style-type:none;padding-top:5px}
.rss_menu ul li{margin-bottom:.4em}
.rss_menu span,.rss_menu label{margin-right:.5em}
.rss_menu ul input{top:0}
.rss_menu dd{margin-left:0;margin-bottom:1em}
.rss_menu #rss_name{width:15em}
.rss_menu button{margin-top:.5em}
.rss_menu label{display:block}
.db_logo{background:transparent url() no-repeat scroll left top;display:block;height:36px;width:100px;text-indent:-9999px}
.res_logo{width:11.539em;left:1.231em;padding-top:.4em;position:absolute}
.res_logo h1{font-weight:normal;margin:0}
.long{padding:.5em 0}
.long h1{line-height:1.15}
.res_logo h1 a{color:#333;display:block;padding:.3em 0;text-shadow:1px 1px 1px rgba(240,240,240,.9)}
.res_tagline{display:none}
.res_logo h1 a,.res_logo h1 a:hover,.res_logo h1 a:visited{text-decoration:none}
h1.img_logo{margin:0}
h1.img_logo a{padding:0}